UnivTrevesV1, Main, Exploration, bibRecord, 000674

Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults

Identifieur interne : 000674 ( Main/Exploration ); précédent : 000673; suivant : 000675

Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults

Auteurs : Carol E. Franz [États-Unis] ; Kelly Spoon [États-Unis] ; Wesley Thompson [États-Unis] ; Richard L. Hauger [États-Unis] ; Dirk H. Hellhammer [Allemagne] ; Kristen C. Jacobson [États-Unis] ; Sonia Lupien [Canada] ; Michael J. Lyons [États-Unis] ; Jeanne Mccaffery [États-Unis] ; Ruth Mckenzie [États-Unis] ; Sally P. Mendoza [États-Unis] ; Matthew S. Panizzon [États-Unis] ; Ana Ramundo [États-Unis] ; Afrand Shahroudi [États-Unis] ; William S. Kremen [États-Unis]

Source :

Psychoneuroendocrinology [ 0306-4530 ] ; 2013.

RBID : Pascal:13-0313055

Descripteurs français

Pascal (Inist)
- Aptitude cognitive, Statut socioéconomique, Hydrocortisone, Sénescence, Système hypothalamohypophysosurrénalien, Stress, Adulte, Enfant, Age mûr, Antiinflammatoire.
Wicri :
- topic : Adulte, Enfant.

English descriptors

KwdEn :
- Adult, Antiinflammatory agent, Child, Cognitive ability, Hydrocortisone, Hypothalamohypophysoadrenal axis, Middle age, Senescence, Socioeconomic status, Stress.

Abstract

In this longitudinal study we investigate the influence of childhood disadvantage on midlife hypothalamic-pituitary-adrenal (HPA) axis regulation. Two mechanisms by which early life stress may affect later pathophysiology are through its influence on cognitive functioning or later socioeconomic (SES) disadvantage. We predicted that individual differences in young adult cognitive ability and midlife SES would mediate the influence of childhood disadvantage on midlife cortisol. On each of three nonconsecutive days, participants provided five salivary cortisol samples corresponding to their diurnal rhythm (N = 727 men; mean age 55, SD = 2.6). We calculated three measures of cortisol regulation (area-under-the curve cortisol reflecting total daytime cortisol output; cortisol-awakening-response; and wake-to-bed slope), averaging scores for each measure across multiple days. Childhood disadvantage combined four dichotomous indicators used previously by Rutter (1985): father low SES; mother education less than 12th grade; major family disruption/separation before age 18; and large family size (more than 5 siblings). The two mediators were a measure of general cognitive ability assessed at age 20 and highest achieved midlife SES. Men from more disadvantaged childhoods were significantly more likely to have dysregulated cortisol at midlife, with higher daytime cortisol levels decades after their childhood experience. Effects of childhood disadvantage were both direct and indirect. Cognitive ability and adult SES, however, only partially mediated the associations between early life stress and midlife cortisol. Specific indirect effects accounted for 33.8% of the total effect of childhood disadvantage [β = 0.12 (0.05; 0.18)] on total daytime cortisol. Associations remained significant after accounting for ethnicity, smoking status, and self-reported depressive symptoms.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755320

Affiliations:

Le document en format XML

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</affiliation>
</author>
<author><name sortKey="Mckenzie, Ruth" sort="Mckenzie, Ruth" uniqKey="Mckenzie R" first="Ruth" last="Mckenzie">Ruth Mckenzie</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Brown University, Psychiatry and Human Behavior</s1>
<s2>Providence, RI 02912</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Rhode Island</region>
<settlement type="city">Providence (Rhode Island)</settlement>
</placeName>
<orgName type="university">Université Brown</orgName>
</affiliation>
</author>
<author><name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>University of California Davis, California National Primate Research Center</s1>
<s2>Davis, CA 95616</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramundo, Ana" sort="Ramundo, Ana" uniqKey="Ramundo A" first="Ana" last="Ramundo">Ana Ramundo</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shahroudi, Afrand" sort="Shahroudi, Afrand" uniqKey="Shahroudi A" first="Afrand" last="Shahroudi">Afrand Shahroudi</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System</s1>
<s2>San Diego, CA 92161</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Psychoneuroendocrinology</title>
<title level="j" type="abbreviated">Psychoneuroendocrinology</title>
<idno type="ISSN">0306-4530</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Psychoneuroendocrinology</title>
<title level="j" type="abbreviated">Psychoneuroendocrinology</title>
<idno type="ISSN">0306-4530</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antiinflammatory agent</term>
<term>Child</term>
<term>Cognitive ability</term>
<term>Hydrocortisone</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Middle age</term>
<term>Senescence</term>
<term>Socioeconomic status</term>
<term>Stress</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Aptitude cognitive</term>
<term>Statut socioéconomique</term>
<term>Hydrocortisone</term>
<term>Sénescence</term>
<term>Système hypothalamohypophysosurrénalien</term>
<term>Stress</term>
<term>Adulte</term>
<term>Enfant</term>
<term>Age mûr</term>
<term>Antiinflammatoire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
<term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In this longitudinal study we investigate the influence of childhood disadvantage on midlife hypothalamic-pituitary-adrenal (HPA) axis regulation. Two mechanisms by which early life stress may affect later pathophysiology are through its influence on cognitive functioning or later socioeconomic (SES) disadvantage. We predicted that individual differences in young adult cognitive ability and midlife SES would mediate the influence of childhood disadvantage on midlife cortisol. On each of three nonconsecutive days, participants provided five salivary cortisol samples corresponding to their diurnal rhythm (N = 727 men; mean age 55, SD = 2.6). We calculated three measures of cortisol regulation (area-under-the curve cortisol reflecting total daytime cortisol output; cortisol-awakening-response; and wake-to-bed slope), averaging scores for each measure across multiple days. Childhood disadvantage combined four dichotomous indicators used previously by Rutter (1985): father low SES; mother education less than 12th grade; major family disruption/separation before age 18; and large family size (more than 5 siblings). The two mediators were a measure of general cognitive ability assessed at age 20 and highest achieved midlife SES. Men from more disadvantaged childhoods were significantly more likely to have dysregulated cortisol at midlife, with higher daytime cortisol levels decades after their childhood experience. Effects of childhood disadvantage were both direct and indirect. Cognitive ability and adult SES, however, only partially mediated the associations between early life stress and midlife cortisol. Specific indirect effects accounted for 33.8% of the total effect of childhood disadvantage [β = 0.12 (0.05; 0.18)] on total daytime cortisol. Associations remained significant after accounting for ethnicity, smoking status, and self-reported depressive symptoms.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>Québec</li>
<li>Rhode Island</li>
</region>
<settlement><li>Montréal</li>
<li>Providence (Rhode Island)</li>
</settlement>
<orgName><li>Université Brown</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name>
</region>
<name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name>
<name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name>
<name sortKey="Jacobson, Kristen C" sort="Jacobson, Kristen C" uniqKey="Jacobson K" first="Kristen C." last="Jacobson">Kristen C. Jacobson</name>
<name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name>
<name sortKey="Mccaffery, Jeanne" sort="Mccaffery, Jeanne" uniqKey="Mccaffery J" first="Jeanne" last="Mccaffery">Jeanne Mccaffery</name>
<name sortKey="Mckenzie, Ruth" sort="Mckenzie, Ruth" uniqKey="Mckenzie R" first="Ruth" last="Mckenzie">Ruth Mckenzie</name>
<name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name>
<name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name>
<name sortKey="Ramundo, Ana" sort="Ramundo, Ana" uniqKey="Ramundo A" first="Ana" last="Ramundo">Ana Ramundo</name>
<name sortKey="Shahroudi, Afrand" sort="Shahroudi, Afrand" uniqKey="Shahroudi A" first="Afrand" last="Shahroudi">Afrand Shahroudi</name>
<name sortKey="Spoon, Kelly" sort="Spoon, Kelly" uniqKey="Spoon K" first="Kelly" last="Spoon">Kelly Spoon</name>
<name sortKey="Thompson, Wesley" sort="Thompson, Wesley" uniqKey="Thompson W" first="Wesley" last="Thompson">Wesley Thompson</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name>
</noRegion>
</country>
<country name="Canada"><region name="Québec"><name sortKey="Lupien, Sonia" sort="Lupien, Sonia" uniqKey="Lupien S" first="Sonia" last="Lupien">Sonia Lupien</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults

Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults

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